![]() ![]() Please help improve this section if you can. The specific problem is: lack of coherent overview. This section may require cleanup to meet Wikipedia's quality standards. ![]() Furanocoumarins may have a stronger effect than naringin. Grapefruit, Seville oranges, and bergamot contain naringin. Polyphenols Ĭitrus fruits may contain various polyphenols, including naringin and furanocoumarins, such as bergamottin, dihydroxybergamottin, and bergapten. Their first published clinical report on grapefruit drug interactions was in 1991. The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989 by a group led by pharmacologist David Bailey. Low drug concentrations can also be caused when the fruit suppresses drug absorption from the intestine. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure. Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. In the first instance, inhibition of drug-metabolizing enzymes results in elevated concentrations of an active drug in the body, which may cause adverse effects.
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